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Evidence available shows that, while IQOS use is not risk-free, switching completely to IQOS presents less risk to your health than continuing to smoke cigarettes

However, the incomplete loss or reversal of the effects of cigarette smoke in mice with Gpr15 deficiency demonstrates that colitis severity is modulated by both Gpr15-dependent and Gpr15-independent mechanisms

Victor DeNoble, describing animal studies that demonstrated the addictiveness of nicotine